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Dr. Zainab Mohammed Almarhoon

Associate Professor

Faculty

كلية العلوم
Building 5 Floor 3 Room no 252
المنشورات
مقال فى مجلة
2013

OxymaPure/DIC: An Efficient Reagent for the Synthesis of a Novel Series of 4-[2-(2-Acetylaminophenyl)-2-oxo-acetylamino] Benzoyl Amino Acid Ester Derivatives

OxymaPure (ethyl 2-cyano-2-(hydroxyimino)acetate) was tested as an
additive for use in the carbodiimide (DIC) approach for the synthesis of a novel series of
α-ketoamide derivatives (4-[2-(2-acetylaminophenyl)-2-oxo-acetylamino]benzoyl amino
acid ester derivatives). OxymaPure showed clear superiority to HOBt/DIC or carbodiimide
alone in terms of purity and yield. The title compounds were synthesized via the ring
opening of N-acylisatin. First, N-acetylisatin was reacted with 4-aminobenzoic acid under
conventional heating as well as microwave irradiation to afford 4-(2-(2-acetamidophenyl)-
2-oxoacetamido)benzoic acid. This α-ketoamide was coupled to different amino acid esters
using OxymaPure/DIC as a coupling reagent to afford 4-[2-(2-acetylaminophenyl)-2-oxoacetylamino]
benzoyl amino acid ester derivatives in excellent yield and purity. The
synthesized compounds were characterized using FT-IR, NMR, and elemental analysis.

نوع عمل المنشور
دكتوراه
رقم الانشاء
18
مجلة/صحيفة
Molecules 2013
الصفحات
14747-14759
مزيد من المنشورات
publications
بواسطة M.H Daghestani,E.M. Al-Olayan, Nadia A Al-Eisa, Z. M. Almarhoon, Sawsan A. Omer, M.A. Elobeid, M.H. Elamin, Z.K. Hassan, P. Virk
2012
publications

Purpose: To assess whether bisphenol A contamination occurred in seven brands of bottled drinking
water in Riyadh, Saudi Arabia.
Methods: Liquid-liquid extraction (using…

بواسطة i A Elobeid1, Zainab M Almarhoon , Promy Virk , Zeinab K Hassan , Sawsan A Omer , Maha ElAmin , Maha H Daghestani and Ebtisam M AlOlayan
2012
publications

Phytotherapy has a promising future in the management of diabetes, considered to be less toxic and free from side effects as compared to the use of synthetic drugs.

2013