ABCA1 C69T gene polymorphism and risk of type 2 diabetes mellitus in a Saudi population
1, KHALID K ALHARBI 1 , IMRAN ALI KHAN 1,*, NASSER M AL-DAGHRI 2 , ANJANA MUNSHI 3 , VANDANA SHARMA 3 , ABDUL KHADER MOHAMMED 2 , KAISER A WANI 2 , YAZEED A AL-SHEIKH 1 , MAY SALEM AL-NBAHEEN 4,5 ,MOHAMMED GHOUSE AHMED ANSARI 2 and RABBANI SYED . 2013
Type 2 diabetes mellitus (T2DM) is a disease induced by complex interactions between environmental factors and certain
genetic factors. Genetic variants in the Adenosine Binding Cassette Transporter Proteins 1 (ABCA1) have been associated
with abnormalities of serum lipid levels of high-density lipoprotein (HDL-C). Decreased serum levels of HDL-C have
often been observed in T2DM cases, and this condition has been considered to be involved in the mechanism of insulin
resistance (IR). Therefore, we investigated possible association between ABCA1 C69T gene polymorphism and T2DMin
a Saudi population. This study was carried out with 380 healthy control subjects and 376 T2DM patients. Genotyping of
ABCA1 C69T polymorphism was carried out by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism
technique. We observed that the frequency of the T allele of the ABCA1 C69T gene was significantly higher in healthy
subjects compared to T2DMpatients (0.28 vs 0.45; p<0.0001; OR (95% CI) = 0.4624 (0.3732–0.5729), and therefore the
T allele may be a protective factor against T2DM in the Saudi population.
Type 2 diabetes mellitus (T2DM) is a disease induced by complex interactions between environmental factors and certain
genetic factors. Genetic variants in the Adenosine Binding Cassette…