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أحمد حسن حسب الله بخيت

Lecturer

باحث

كلية الصيدلة
2أ 125
publication
Journal Article
2018

Mirtazapine. In Profiles of Drug Substances, Excipients and Related Methodology .‏

, Al-Majed, A., Bakheit, A. H., Alharbi, R. M., & Aziz, H. A. A. . 2018

Mirtazapine is one of antidepression which is used mainly in the treatment of depression, moreover, it is sometimes used in the treatment of anxiety disordersinsomnianausea, and vomiting, and to produce weight gain when desirable. The action of mirtazapine is an antagonist of certain adrenergic and serotoninreceptors, and, furthermore, the drug is used strong as antihistamine, and it is occasionally defined as a noradrenergic and specific serotonergic antidepressant(NaSSA).

The comprehensive profile of mirtazapine gives more detailed information about nomenclature, formulae, elemental analysis, and appearance. In addition, the numerous methods of drug synthesis are summarized. Also the profile covers the physicochemical properties as: the value of pKa, drug solubilitymelting point, X-ray powder diffraction, and analysis methods for example: (compendial, electrochemical, spectroscopic, and method of chromatographic). Besides that, the profile covered pharmacological profile and clinical pharmacokinetics in subtitle's (absorption, distribution, metabolism, and elimination). About 100 references were given as a proof of the above-mentioned studies.

Publisher Name
Profiles of Drug Substances, Excipients and Related Methodology
Volume Number
43
Magazine \ Newspaper
Profiles of Drug Substances, Excipients and Related Methodology
Pages
209-254
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Published in:
Profiles of Drug Substances, Excipients and Related Methodology
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