Effect of Centella asiatica Formulation on the Pharmacokinetics of Amitriptyline in Rats: A Herb-Drug Interaction Study
, Fowad KHURSHID, Jeyabalan GOVINDASAMY, Habibullah KHALILULLAH, Mohammed Shivli NOMANI, Mudassar SHAHID , Md Ruhal AIN & Mohammad S. ALSULTAN . 2018
SUMMARY. This study evaluates the effect of Centella asiatica formulation on the pharmacokinetics of amitriptyline in rats. In this study, rats were randomly divided into two groups (n = 6 each) which were served as a control (amitriptyline alone) and treatment group (amitriptyline with C. asiatica), respectively. Rats were administered vehicle saline or C. asiatica (62.5 mg/kg, p.o. daily for 7 days), then administered a single amitriptyline dose (25 mg/kg, p.o.) on day 8. Plasma samples were analyzed for amitriptyline concentration using a developed and validated reversed-phase high-performance liquid chromatography (RPHPLC) method. Pharmacokinetic parameters were calculated using non-compartmental analysis. The coadministration of C. asiatica with amitriptyline resulted in increased plasma maximum concentration (Cmax), area under the curve (AUC0–24) and elimination half-life (t1/2) by 14.34, 23, and 13.81%, respectively. The present study demonstrated that C. asiatica extract has the potential to alter the pharmacokinetics of amitriptyline by a significant reduction in amitriptyline clearance and an increase in its AUC, Cmax and t1/2.
Purpose: This study aimed to explore the physician’s knowledge and identify the perceived barriers that prevent family medicine physicians from engaging in deprescribing among older patients.
SUMMARY. This study evaluates the effect of Centella asiatica formulation on the pharmacokinetics of amitriptyline in rats. In this study, rats were randomly divided into two groups (n = 6 each)…
Interactions between herbs and drugs may increase or decrease the pharmacological or toxicological effects of either component. Experimental data on the pharmacokinetic interactions between herbal…