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إبراهيم بن محمّد الهزّاع IBRAHIM M. ALHAZZA

Professor

عضو هيئة تدريس بقسم علم الحيوان

كلية العلوم
أب60 الدور الارضي مبنى 5، AB60 G FLOOR BUILDING5، Lab. AB73

Comparative efficacy of ternary Cu (II) complex and Zn (II)-complex in amelioration of carbon tetrachloride-induced hepatotoxicity in vivo

Copper Zinc Metal complex Carbon tetrachloride Hepatotoxicity

Abstract: Cu (II) and Zn (II) are two of the most favored metals in synthesis chemistry, encompassing their therapeutic potentials. The present study aims to evaluate the comparative ameliorative potential of a group B carcinogen, CCl4-induced hepatotoxicity, by our recently synthesized and characterized ternary Cu and Zn-based complexes in vivo. Three groups of rats were treated with CCl4 alone and with the combination of Cu (II) complex and Zn (II) complex beside the control negative group without any treatment. After completion of the treatment, the samples were subjected to biochemical and histological analysis. The analysis demonstrated extensive alteration in redox status, liver markers, and hepatotoxicity markers in the CCl4, treated group compared to the control group. However, the Cu (II) complex showed significant improvement in most of the parameters under the study. Also, histopathological evaluation and comet assay further consolidated the findings. Hence, this investigation reveals that Cu (II) complex has more substantial ameliorative potential in ceasing CCl4-induced hepatotoxic insults. Therefore, the ternary Cu (II) complex act as a more potent chemotherapeutic agent in cancer treatment with milder side effects than the Zn (II) complex.

Publication Work Type
مقال
more of publication
publications

Abstract: Cu (II) and Zn (II) are two of the most favored metals in synthesis chemistry, encompassing their therapeutic potentials.

by Iftekhar Hassan a,1 , Rais Ahmad Khan b,1 , Jameel Al-Tamimi a , Hossam Ebaid a , Fohad Mabood Husain c , Ibrahim M. Alhazza
2022
publications

 

by Nouf Omar Alafaleq, Alya Alomari, Mohd Shahnawaz Khan*, Gouse M. Shaik, Afzal Hussain, Faheem Ahmed, Iftekhar Hassan, Ibrahim M. Alhazza, Majed S. Alokail, Amal Majed H. Alenad, Nasimudeen R. Jabir, and Shams Tabrez*
2022
publications

Abstract: Because of the potential bioactivities, nanoparticles have engendered hope in scientific communities for developing novel therapeutic strategies.

by Ahmed M. Rady*, Hossam Ebaid, Mohamed Habila, Iftekhar Hassan, Jameel Al-Tamimi, Ibrahim M. Alhazza, Mohamed S. Moshab, Zeid A. ALOthman
2023