Skip to main content
User Image

نواف بن مساعد العتيبي Nawaf Musaid Alotaibi

Demonstrator

عضو هيئة تدريس Demonstrator, College of Medicine, Faculty of Internal Medicine, Pulmonology Unit

كلية الطب
مبنى كلية الطب، الدور الثاني، قسم الباطنة

The role of beta-blockers in the management of chronic obstructive pulmonary disease

Alotaibi, Nawaf M . 2018

COPD Beta-blockers Lung function

Introduction: The use of beta-blockers in chronic obstructive pulmonary disease (COPD) is controversial, primarily due to concerns that they may worsen lung function and attenuate bronchodilator response.

 

Areas covered: This review summarizes the reasons for and against the use of beta-blockers in COPD by evaluating the literature on the effects of these drugs on lung function, exacerbation rate, and mortality. The safety of beta-blockers in COPD patients with concomitant heart failure, an entity that is not always distinguishable from COPD exacerbations, is also explored.

 

Expert commentary: The use of cardioselective beta-blockers appears safe in the management of cardiac comorbidities associated with COPD and may lower exacerbation and mortality risk. There is a growing body of evidence demonstrating the safety of beta-blockers in patients with acute heart failure, acute respiratory failure or sepsis, entities that could occur simultaneously with COPD exacerbations. However, randomized controlled trials are still lacking to confirm these results.

Magazine \ Newspaper
Expert Review of Respiratory Medicine
more of publication
publications

Background: Etiologies of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are heterogeneous. We phenotyped severe AECOPD based on molecular pathogen…

by Nawaf M Alotaibi, Virginia Chen, Zsuzsanna Hollander, Jonathon A Leipsic , Cameron J Hague, Darra T Murphy, Mari L DeMarco, J. Mark FitzGerald, Bruce M McManus, Raymond T Ng, Don D Sin
2019
publications

Rationale: Lung dysbiosis promotes airway inflammation and decreased local immunity, potentially playing a role in the pathogenesis of acute exacerbations of COPD (AECOPD). We determined the…

by Fernando Sergio Leitao Filho, Nawaf M Alotaibi, David Ngan, Sheena Tam , Julia Yang, Zsuzsanna Hollander, Virginia Chen, J. Mark FitzGerald, Corey Nislow, Janice M leung, SF Paul Man, Don D Sin
2018
publications

Introduction: The use of beta-blockers in chronic obstructive pulmonary disease (COPD) is controversial, primarily due to concerns that they may worsen lung function and attenuate bronchodilator…

by Nawaf M Alotaibi, Fernando Sergio Leitao Filho, Kei Yamasaki, David A Ngan, Don D Sin
2018