Fabrication of core-shell structured nanofibers of poly (lactic acid) and poly(vinyl alcohol) by coaxial electrospinning for tissue engineering
Abd‑Elkader, Omar H. . 2018
Poly Lactic Acid (PLA) nanofiber scaffold has enjoyed great interest as a candidate bioactive material for tissue
regeneration. However, the hydrophobic nature of PLA and its weak mechanical properties with poor ductility
and low strength hinder its practical applications. In this study, coaxial electrospinning was used to fabricate
core-shell composite nanofibers with PLA in the core and PVA in the shell with significant enhancements in the
surface wetting and mechanical properties. More specifically, the core/shell-structured PLA/PVA nanofiber mat
exhibited excellent hydrophilic properties with a water contact angle of 27 ± 1.5° compared to 110° ± 2.5° for
pristine PLA. Moreover, the fabricated composite nanofibers displayed nearly 254% and 175% increase in tensile
strength and strain at failure, respectively, compared to pristine PLA (14.5 MPa vs. 4.1 MPa for tensile strength
and 110% vs. 40% for ductility). The coaxial electrospun PLA(core)/PVA(shell) nanofibers also showed suitable
properties for proliferation, and attachment of human embryonic kidney cells (HEK-293). These excellent
combined mechanical, surface wetting, and cytocompatibility properties clearly demonstrate the potential applications
of the synthetic core-shell PLA/PVA composite nanofibers in biomedical and tissue regeneration.
Poly Lactic Acid (PLA) nanofiber scaffold has enjoyed great interest as a candidate bioactive material for tissue
regeneration. However, the hydrophobic nature of PLA and its weak mechanical…
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